What is hepatitis B 145? ——Analysis of key indicators in two-and-half tests for hepatitis B
Recently, topics related to hepatitis B have once again become the focus of public attention, especially the discussion on "hepatitis B 145 positive". This article will structure the meaning, clinical significance and common problems of hepatitis B 145 based on the hot topics of the entire network for the past 10 days.
1. Basic concepts of two-half test for hepatitis B
Hepatitis B 145 refers to the 1st, 4th and 5th items of the two-half hepatitis B (five hepatitis B items). The specific corresponding indicators are as follows:
| Serial number | Testing items | Abbreviation | Medical name |
|---|---|---|---|
| 1 | Hepatitis B surface antigen | HBsAg | Positive indicates hepatitis B virus infection |
| 4 | Hepatitis B e antibody | HBeAb | Viral replication weakening sign |
| 5 | Hepatitis B core antibodies | HBcAb | Has been infected or has been infected |
2. The clinical significance of positive hepatitis B 145
According to the recent hot discussions in medical forums, the 145 positive combination usually represents the following three situations:
| possibility | feature | Percentage |
|---|---|---|
| 1. Hepatitis B mist three positive | Low replication status of virus | About 60% of cases |
| 2. Recovery period transition phase | Surface antigens are about to turn negative | About 25% of cases |
| 3. Hidden hepatitis B infection | HBV-DNA test is required to confirm | About 15% of cases |
3. Answers to recent popular online questions
Combining Baidu Index and Zhihu Hot List data, we have sorted out three high-frequency questions:
1. Will 145 be positive be contagious?
It is still contagious, but its infectivity is lower than that of Da Sanyang (135 positive), and the viral load needs to be confirmed through HBV-DNA detection.
2. Do you need treatment?
The 2023 "Guidelines for the Prevention and Treatment of Chronic Hepatitis B" points out that if the ALT is consistently abnormal, ②HBV-DNA positive, antiviral treatment is recommended.
3. Can it turn negative?
Clinical data show that about 1-3% of 145 positive patients can achieve natural negative surface antigen conversion, and new drugs such as interferon can increase the negative conversion rate to 5-8%.
4. Latest research trends (hot spots in the past 10 days)
| date | Research progress | source |
|---|---|---|
| 2023.11.15 | Tsinghua University discovers novel hepatitis B surface antigen inhibitor | Sub-Issue of Nature |
| 2023.11.18 | my country launches the second phase of the clinical cure of hepatitis B | Hepatology Branch of Chinese Medical Association |
| 2023.11.20 | AI predicts the accuracy of hepatitis B fibrosis degree to reach 89% | International Conference on Liver Diseases |
5. Daily precautions
According to popular science suggestions from platforms such as Dingxiang Doctor:
1. Recheck liver function and HBV-DNA every 3-6 months
2. Avoid alcohol and hepatotoxic drugs
3. Family members should be vaccinated
4. Maintain regular routine and exercise moderately
Conclusion:The positive rate of hepatitis B 145 requires a comprehensive judgment based on multiple indicators. The medical community has made significant progress in the field of hepatitis B cure recently. It is recommended that patients follow up regularly and obtain the latest treatment plan in a timely manner.
(The full text has a total of about 850 words, and the data is as of November 2023)
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